For the mind that is set on the flesh is hostile to God, for it does not submit to God’s law; indeed, it cannot. Those who are in the flesh cannot please God.
It doesn’t get any more straightforward than that, but there are those who are trying to promote the concept that our works are able to help us find salvation, that we can be pleasing in God’s eyes by “doing good” as Pope Francis has stated. This couldn’t be further from the truth. What we do as humans that isn’t specifically repentant belief in Christ cannot bring us salvation. You can give all of your money to charity, travel the world giving people food, and run into a burning building to save children hiding in a closet, but if you don’t also believe with all of your heart that Christ is your Lord who died on the cross for your sins, you’re soul is still lost.